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Xalatan 0.005% (Latanoprost) Patient Information Guide in Thailand

What is Xalatan 0.005%?

Xalatan 0.005% (Latanoprost) is classified as a prostaglandin analog used primarily to manage certain eye conditions. In Thailand, this formulation is utilized to lower elevated intraocular pressure (IOP) associated with open-angle Glaucoma or ocular Hypertension. Latanoprost works by promoting fluid drainage from the eye, thereby reducing pressure that can damage the optic nerve. This medication is supplied in a sterile liquid solution contained within a small bottle. It has received approval from relevant health authorities for its intended use in managing elevated eye pressure.

Who Should Use Xalatan 0.005%?

Individuals who fit the following profiles are typically considered candidates for using Latanoprost:

• Adults diagnosed with open-angle glaucoma.
• Patients experiencing ocular hypertension (high pressure inside the eye).
• Those requiring management of elevated intraocular pressure, as advised by their eye care specialist.
• Individuals with proven tolerance to prostaglandin analogs.

How Does It Work?

Latanoprost functions as a synthetic prostaglandin F2α analog, chemically mimicking a naturally occurring substance in the body that helps regulate fluid dynamics. Its mechanism involves increasing the outflow of aqueous humor, the fluid filling the front part of the eye, primarily through the uveoscleral pathway. By enhancing this drainage route, Latanoprost effectively lowers the pressure inside the eye. This sustained pressure reduction is crucial because high intraocular pressure is the main risk factor for progressive damage to the optic nerve, leading to irreversible vision loss. It does not affect the brain or central nervous system, and its action is confined locally to the eye structure.

Why Choose Xalatan 0.005%?

The primary advantage of using Xalatan 0.005% lies in its highly targeted efficacy for pressure control. When compared to generic Latanoprost formulations available, the established brand formulation often guarantees consistency in the inactive ingredients and delivery system, which can be important for sensitive ocular tissues. For patients struggling with consistent pressure readings, this specific, well-characterized product offers a reliable therapeutic option. It is generally administered only once daily, providing long-lasting pressure lowering with minimal disruption to daily activities.

Dosage, Administration, Lifestyle and Dietary Recommendations

Recommended Dosage

For adults, the typical prescribed dose is one drop of 2.5ml formulation applied to the affected eye(s) once daily, preferably in the evening. Consistency in the time of application is key to maintaining stable pressure throughout the 24-hour cycle. Healthcare providers tailor this regimen based on individual pressure responses.

How to Take

Administering Latanoprost eye drops requires precise technique to maximize absorption and minimize contamination.

• Wash hands thoroughly before handling the bottle.
• Gently pull down the lower eyelid to form a small pocket.
• Hold the dropper tip close to the eye without touching it or the eyelid.
• Apply the single drop into the pocket created by the lower lid.
• Gently close the eye and apply light pressure with a finger to the inner corner of the eye (near the nose) for about one minute; this helps limit systemic absorption.
• Wipe away any excess liquid immediately from the skin area around the eye.

Missed Dose

If a dose is forgotten, it should be applied as soon as you remember, unless it is nearly time for the next scheduled application. If that is the case, skip the missed dose entirely and resume the regular schedule. Do not double the dose to make up for a forgotten application.

Overdose

In the unlikely event of an eye overdose (applying multiple drops), rinse the eye thoroughly with lukewarm water. Inform your eye care professional immediately regarding the excessive administration. Systemic overdose symptoms are rare, but if significant symptoms like dizziness or Nausea occur, seek immediate consultation.

Special Populations

• Elderly Patients: No specific dosage alteration is generally required, as systemic absorption is minimal, but ongoing monitoring is essential.
• Pediatric Patients: Safety and efficacy data in children may be limited; usage requires strict specialist guidance.
• Hepatic/Renal Impairment: Since Latanoprost is significantly metabolized by the liver, caution is advised for individuals with severe liver impairment, though dose adjustments are not always mandated.

Lifestyle & Diet

• Contact Lenses: Remove soft contact lenses before applying the drops; wait at least 15 minutes before reinserting them.
• Eye Makeup: Avoid applying eye makeup until the drops have fully absorbed.
• Alcohol/Smoking: While no direct interaction exists, smoking and excessive alcohol consumption negatively impact overall ocular health and should be minimized.

Precautions and Warnings

A notable change to be aware of when using Latanoprost is the potential for gradual, permanent changes in eye color, often turning lighter irises (blue, green, hazel) to brown. This change is typically subtle and may not appear for months or years. Furthermore, be cautious if you have had recent eye surgery or certain eye infections, as this requires careful monitoring by your specialist. Always inform your eye care provider about any history of eye Inflammation (Uveitis or iritis).

Drug Interactions

Potential Side Effects

Common Side Effects

These effects are usually mild and often temporary as the eye adjusts to the medication.

• Increased brown pigmentation of the iris.
• Mild eye irritation, stinging, or burning sensation upon application.
• Localized itching or redness of the conjunctiva.
• Foreign body sensation in the eye.

Less Common Side Effects

• Headache.
• Upper Respiratory Tract Infection symptoms.
• Muscle or joint Pain (arthralgia).
• Blurred vision immediately following application.

Serious Side Effects

If you experience any of the following, seek advice from your eye care specialist promptly:

• Severe eye pain or sudden vision changes.
• Unusual swelling of the eyelid or persistent, severe redness.
• Development of corneal erosion or clouding.

Who Should Avoid This Medication?

Latanoprost is specifically contraindicated (should not be used) under the following circumstances:

• Known hypersensitivity or allergic reaction to Latanoprost or any component of the formulation.
• History of active inflammation within the eye (e.g., uveitis, iritis).
• Individuals with certain known contraindications to prostaglandin analogs.

Storage Instructions

Proper storage maintains the effectiveness and sterility of the eye drops.

• Store the unopened bottle in a refrigerator (2°C to 8°C).
• Once the bottle has been opened or placed into immediate use, it can generally be stored at controlled room temperature (below 30°C), but must be discarded after 28 days, regardless of how much solution remains.
• Protect the bottle from direct light exposure.
• Keep out of reach of children and pets.

Xalatan 0.005% Alternatives

While Xalatan is a recognized brand name, other active molecules are frequently utilized for lowering intraocular pressure.

Frequently Asked Questions

How long will it take to see a reduction in eye pressure?

Significant lowering of intraocular pressure typically begins within a few hours of the first dose, with the effect stabilizing over several days. Consistent daily use is necessary to maintain the achieved pressure level over the long term.

Can I use eye makeup while undergoing treatment with Latanoprost?

It is advised to wait until the eye drop has been fully absorbed, usually about 15 minutes, before applying any eye cosmetics. Direct contact between makeup products and the medication tip should also be avoided to prevent contamination.

What if my eye color changes-is this dangerous?

The change in iris color to brown is usually cosmetic and not associated with vision impairment or underlying ocular disease. However, the change is permanent, so it is crucial to discuss this potential side effect with your eye specialist during follow-up appointments.

Is Xalatan 0.005% effective for all types of glaucoma?

Latanoprost is primarily indicated for open-angle glaucoma and ocular hypertension. It is generally not the first-line treatment for angle-closure glaucoma, which requires different mechanical or surgical interventions.

How long can I safely use this medication?

As this is a chronic condition management therapy, Latanoprost is often intended for long-term, continuous use as directed by your eye specialist to prevent optic nerve damage. Your specialist will monitor your condition over time to determine the appropriate treatment duration.

Does this eye drop affect my ability to drive at night?

While Latanoprost is generally not known to cause significant systemic Drowsiness, transient blurry vision immediately after application might temporarily affect night vision or tasks requiring sharp focus. Applying the drop well before driving is recommended.

Why might my eye specialist suggest using this at night instead of morning?

The concentration of prostaglandin-like substances naturally peaks at night, making evening dosing align optimally with the eye’s natural physiology for sustained pressure control throughout the following day.

Glossary

• Aqueous Humor: The clear, watery fluid filling the front segment of the eye, maintained by balance between production and drainage.
• Intraocular Pressure (IOP): The pressure inside the eye, measured in millimeters of mercury (mmHg).
• Prostaglandin Analog: A class of medications structurally similar to naturally occurring prostaglandins, used here to promote fluid outflow.
• Uveoscleral Pathway: One of the two major routes through which the excess fluid (aqueous humor) drains out of the eye.

Disclaimer

This article provides general, evidence-based educational information regarding Lamisul (Latanoprost) intended for knowledgeable adults in Thailand. It is not a substitute for professional medical consultation, diagnosis, or tailored treatment planning. Information provided here should never be used to self-diagnose or determine appropriate use for any specific medical condition. Always defer to the specific instructions provided by your qualified eye care professional. Our service facilitates access to established health information but does not provide medical advice or treatment recommendations.

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